Basic Information |
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| Product Name： | APIGENIN |
| CAS： | 520-36-5 |
| English Synonyms： | 4,5,7-TRIHYDROXYFLAVONE ; 5,7-DIHYDROXY-2-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE ; 2-(P-HYDROXYPHENYL)-5,7-DIHYDROXYCHROMONE ; CHAMOMILE ; VERSULIN ; APIGENOL ; 4',5,7-TRIHYDROXYFLAVONE ; CI NATURAL YELLOW 1 ; 5,7,4'-TRIHYDROXYFLAVONE ; 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE ; 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE ; MATRICARIA OIL ; APIGENIN ; APIGENINE ; 7,4,5'-TRIHYDROXYFLAVONE |
| MDL Number.： | MFCD00006831 |
| H bond acceptor： | 5 |
| H bond donor： | 3 |
| Smile： | c1cc(ccc1c2cc(=O)c3c(cc(cc3o2)O)O)O |
| InChi： | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
| InChiKey： | InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N |
Property |
|
| Melting Point： | >300 DEG C(LIT)/345-350℃/345-350℃ |
| Comments： | ASSAY METHOD: =>75% (HPLC) BIOCHEM/PHYSIOL ACTIONS: A PLANT FLAVONOID THAT HAS BEEN FOUND TO INHIBIT CELL PROLIFERATION BY ARRESTING THE CELL CYCLE AT THE G2/M PHASE. INHIBITION OF GROWTH THROUGH CELL CYCLE ARREST AND INDUCTION OF APOPTOSIS APPEAR TO BE RELATED TO INDUCTION OF P53.INHIBITS PMA-MEDIATED TUMOR PROMOTION BY INHIBITING PROTEIN KINASE C1 AND THE RESULTING SUPPRESSION OF ONCOGENE EXPRESSION. IT HAS ALSO BEEN REPORTED TO INHIBIT TOPOISOMERASE I-CATALYZED DNA RE-LIGATION AND ENHANCE GAP JUNCTIONAL INTERCELLULAR COMMUNICATION RTECS: LK9276000 STORAGE TEMPERATURE: -20 DEG C TOTAL IMPURITIES: WGK: 3 |
| Information： | BIOLOGICAL SOURCE: FROM PARSLEY |
Safety information |
|
| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H315-H319-H335 |
| Precautionary statements： | P261-P305 + P351 + P338 |
| hazard symbol： | Xi |
| Risk Code： | R:36/37/38 |
| Safe Code： | S:26-36 |
| WGK Germany： | 3 |
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