Basic Information |
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| Product Name： | ALOE-EMODIN |
| CAS： | 481-72-1 |
| English Synonyms： | ALOE-EMODINE ; ALOE-EMODIN ; 1,8-DIHYDROXY-3-HYDROXYMETHYL-9,10-ANTHRACENEDIONE ; 9,10-ANTHRACENEDIONE,1,8-DIHYDROXY-3-(HYDROXYMETHYL)- ; 1,8-DIHYDROXY-3-(HYDROXYMETHYL)ANTHRACENE-9,10-DIONE ; 3-HYDROXYMETHYLCHRYSAZINE ; 1,8-DIHYDROXY-3-(HYDROXYMETHYL)ANTHRAQUINONE ; 3-(HYDROXYMETHYL)CHRYSAZIN ; RHABARBERONE |
| MDL Number.： | MFCD00017373 |
| H bond acceptor： | 5 |
| H bond donor： | 3 |
| Smile： | c1cc2c(c(c1)O)C(=O)c3c(cc(cc3O)CO)C2=O |
| InChi： | InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 |
| InChiKey： | InChIKey=YDQWDHRMZQUTBA-UHFFFAOYSA-N |
Property |
|
| Melting Point： | 223～224℃ |
| Comments： | ASSAY METHOD: HPLC BIOCHEM/PHYSIOL ACTIONS: INCREASES THE CONTRACTION OF INTESTINAL SMOOTH MUSCLE BY RELEASING ENDOGENOUS ACETYLCHOLINE. ANTI-TUMOR ACTIVITY IS ASSOCIATED WITH AN INCREASED PRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) THAT, IN TURN, REDUCES THE MITOCHONDRIAL TRANSMEMBRANE ELECTRICAL POTENTIAL, THUS INDUCING A PERMEABILITY TRANSITION THAT SETS IN MOTION A SERIES OF EVENTS CULMINATING IN CELLULAR APOPTOSIS. GENOTOXICITY AND MUTAGENICITY APPEAR TO BE DUE TO THE INHIBITION OF TOPOISOMERASE II ACTIVITY BY ALOE EMODIN BIOCHEM/PHYSIOL ACTIONS: LAXATIVE/CATHARTIC COMPOUND RTECS: CB6712200 SHELF LIFE: LIMITED SHELF LIFE, EXPIRY DATE ON THE LABEL STORAGE TEMPERATURE: 2-8 DEG C WGK: 3 |
| Specification： | ANALYTICAL STANDARD |
Safety information |
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| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H315,H319,H335 |
| Precautionary statements： | P261,P305+P351+P338 |
| hazard symbol： | Xi |
| Risk Code： | R:36/37/38 |
| Safe Code： | S:26,36 |
| WGK Germany： | 3 |
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