Basic Information |
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| Product Name： | MICONAZOLE NITRATE |
| CAS： | 75319-48-1 ;22916-47-8 ;22832-87-7 ;22832-37-7 ;228321-87-7 |
| English Synonyms： | DAKTACORT ; ANDERGIN ; 1-[2-(2,4-DICHLOROPHENYL)-2-[(2,4-DICHLOROPHENYL)METHOXY]ETHYL]-1H-IMIDAZOLE NITRATE ; (±)-MICONAZOLE NITRATE SALT ; 1-[2-(2,4-DICHLOROBENZYLOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE ; MICONAZOLE NITRATE ; FUNGISDIN ; 1-(2,4-DICHLORO-BETA-[(2,4-DICHLOROBENZYL)OXY]PHENETHYL)IMIDAZOLE NITRATE ; MICONAZOLE ; 1-(2,4-DICHLORO-BETA-[(2,4-DICHLOROBENZYL)OXY]PHENETHYL)IMIDAZOLE NITRATE SALT ; (+/-)-MICONAZOLE NITRATE ; ALBISTAT ; (+/-)-MICONAZOLE NITRATE SALT |
| MDL Number.： | MFCD00058161 |
| H bond acceptor： | 3 |
| H bond donor： | 0 |
| Smile： | c1cc(c(cc1Cl)Cl)COC(Cn2ccnc2)c3ccc(cc3Cl)Cl.[N+](=O)(O)[O-] |
| InChi： | InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4) |
| InChiKey： | InChIKey=MCCACAIVAXEFAL-UHFFFAOYSA-N |
Property |
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| Comments： | BIOCHEM/PHYSIOL ACTIONS: MICONAZOLE INTERACTS WITH 14-ALPHA DEMETHYLASE, A CYTOCHROME P-450 ENZYME NECESSARY FOR ERGOSTEROL BIOSYNTHESIS. THE INHIBITION OF ERGOSTEROL RESULTS IN INCREASED CELLULAR PERMEABILITY CAUSING LEAKAGE OF CELLULAR CONTENTS. MICONAZOLE MAY ALSO INHIBIT ENDOGENOUS RESPIRATION, INTERACT WITH PHOSPHOLIPIDS IN THE CELL MEMBRANE, INHIBIT THE TRANSFORMATION OF YEASTS TO MYCELIAL FORMS, INHIBIT PURINE UPTAKE, AND INTERFERE WITH TRIGLYCERIDE AND PHOSPHOLIPID BIOSYNTHESIS GENERAL DESCRIPTION: THIS PRODUCT IS PROVIDED AS DELIVERED AND SPECIFIED BY THE ISSUING PHARMACOPOEIA. ALL INFORMATION PROVIDED IN SUPPORT OF THIS PRODUCT, INCLUDING MSDS AND ANY PRODUCT INFORMATION LEAFLETS HAVE BEEN DEVELOPED AND ISSUED UNDER THE AUTHORITY OF THE ISSUING PHARMACOPOEIA. FOR FURTHER INFORMATION AND SUPPORT PLEASE GO TO THE WEBSITE OF THE ISSUING PHARMACOPOEIA OTHER NOTES: SALES RESTRICTIONS MAY APPLY |
Safety information |
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| Symbol： |
GHS07
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| Signal word： | Warning |
| Hazard statements： | H302,H317 |
| Precautionary statements： | P280 |
| hazard symbol： | Xn |
| Risk Code： | R:22,43 |
| Safe Code： | S:36/37 |
| WGK Germany： | 3 |
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