Basic Information |
|
| Product Name： | DEMECOLCINE |
| CAS： | 477-30-5 |
| English Synonyms： | OMAINE ; COLCEMIDE ; COLCEMID(TM) ; DEMECOLCIN ; COLCHAMINE ; COLCEMID ; DEACETYLMETHYLCOLCHICINE ; COLCEMIDE(R) ; (7S)-6,7-DIHYDRO-1,2,3,10-TETRAMETHOXY-7-(METHYLAMINO)-BENZO[A]HEPTALEN-9(5H)-ONE ; (S)-1,2,3,10-TETRAMETHOXY-7-(METHYLAMINO)-6,7-DIHYDROBENZO[A]HEPTALEN-9(5H)-ONE ; COLCHICINE, N-DEACETYL-N-METHYL- ; N-DEACETYL-N-METHYLCOLCHICINE ; COLCHAMIN ; N-METHYL-N-DEACETYL-COLCHICINE ; N-METHYL-N-DESACETYLCOLCHICINE ; OMAIN ; DEMECOLCINE ; 6,7-DIHYDRO-1,2,3,10-TETRAMETHOXY-7-(METHYLAMINO) BENZO (ALPHA) HEPTALEN-9(5H)-ONE ; REICHSTEIN'S F |
| MDL Number.： | MFCD00075459 |
| H bond acceptor： | 6 |
| H bond donor： | 1 |
| Smile： | CN[C@H]1CCc2cc(c(c(c2-c3c1cc(=O)c(cc3)OC)OC)OC)OC |
| InChi： | InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1 |
| InChiKey： | InChIKey=NNJPGOLRFBJNIW-HNNXBMFYSA-N |
Property |
|
| Comments： | ASSAY METHOD: HPLC BIOCHEM/PHYSIOL ACTIONS: BLOCKS MITOSIS AT METAPHASE. OFTEN IN KARYOTYPING AND CELL CYCLE RESEARCH IT IS DESIRABLE TO INCREASE THE YIELD OF MITOTIC CELLS IN A PARTICULAR PHASE OF THE CELL CYCLE. THIS CAN BE ACHIEVED IN A VARIETY OF WAYS WITH THE MOST POPULAR BEING THE USE OF A CELL CYCLE SYNCHRONIZING AGENT SUCH AS DEMECOLCINE. DEMECOLCINE WILL ARREST CELLS IN METAPHASE WITH NO REMARKABLE EFFECT ON THE BIOCHEMICAL EVENTS IN MITOTIC CELLS OR IN SYNCHRONIZED G1 AND S PHASE CELLS. WHITE BLOOD CELLS ARE OFTEN TREATED WITH DEMECOLCINE TO ARREST CELLS IN METAPHASE BIOCHEM/PHYSIOL ACTIONS: DEPOLYMERIZES MICROTUBULES OTHER NOTES: BINDS TUBULIN HENCE INTERFERING WITH MICROTUBULE-DEPENDENT CELL FUNCTION RIDADR: UN 2811 6.1/PG 2 RTECS: GH0800000 STORAGE TEMPERATURE: 2-8 DEG C UNSPSC: 12352200 WGK: 3 |
| Information： | SUM OF ENANTIOMERS |
| Concentration： | 10μg/mLinHBSS |
Safety information |
|
| Symbol： |
GHS06
|
| Signal word： | Danger |
| Hazard statements： | H300 |
| Precautionary statements： | P264-P301 + P310 |
| hazard symbol： | T |
| Risk Code： | R:25 |
| Safe Code： | S:22-24/25-45 |
| WGK Germany： | 3 |
* If the product has intellectual property rights, a license granted is must or contact us.
2010-2025 © Chemical Cloud Database. ALL Rights Reserved.浙ICP备11020424号-1
浙公网安备 33010802004002号
中文版