Basic Information |
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| Product Name： | 4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORIDE |
| CAS： | 74938-88-8 |
| English Synonyms： | (P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE ; P-APMSF ; P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE ; P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL ; 4-AMIDINOBENZYLSULFONYL FLUORIDE HYDROCHLORIDE ; P-APMSF HYDROCHLORIDE ; (4-CARBAMIMIDOYLPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE ; 4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORIDE ; APMSF HCL ; 4-AMIDINOPHENYLMETHANESULPHONYL FLUORIDE HYDROCHLORIDE ; 4-AMIDINOPHENYLMETHANESULFONYL-FLUORIDE-HCL ; APMSF HYDROCHLORIDE |
| MDL Number.： | MFCD00078902 |
| H bond acceptor： | 4 |
| H bond donor： | 2 |
| Smile： | c1cc(ccc1CS(=O)(=O)F)C(=N)N.Cl |
| InChi： | InChI=1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H |
| InChiKey： | InChIKey=KHLLRHIUKOJXLL-UHFFFAOYSA-N |
Property |
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| Melting Point： | APPROX 205 DEG C (DEC) |
| Comments： | APPLICATION: APMSF WAS USED TO STUDY THE GLUCAGON-RECEPTOR INTERACTION APPLICATION: INHIBITION OF CAMP FORMATION LED TO THE CONCLUSION THAT THERE WAS A PREVIOUSLY UNEXPECTED SERINE RESIDUE IN THE ACTIVE SITE WHICH MAY OPERATE ON THE RECEPTOR BY A MECHANISM SIMILAR TO SERINE PROTEASES ASSAY METHOD: AT BIOCHEM/PHYSIOL ACTIONS: IRREVERSIBLE INHIBITOR OF SERINE PROTEASES WITH LYSINE OR ARGININE SUBSTRATE SPECIFICITIES. EFFECTIVE CONCENTRATION 10-100 MICROMOLE. FREQUENTLY USED TO CHARACTERIZE NEWLY DISCOVERED PROTEASES OTHER NOTES: AN IRREVERSIBLE INHIBITOR OF SERINE PROTEASES STORAGE TEMPERATURE: -20 DEG C UNSPSC: 12352200 WGK: 3 |
Safety information |
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| WGK Germany： | 3 |
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