Basic Information |
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| Product Name： | PERTUSSIS TOXIN |
| CAS： | 70323-44-3 |
| English Synonyms： | IAP ; ISLET ACTIVATING PROTEIN ; HISTAMINE-SENSITIZING FACTOR ; PERTUSSIGEN ; PERTUSSIS TOXIN ; PTX ; HOLOTOXIN |
| MDL Number.： | MFCD00131841 |
| H bond acceptor： | 0 |
| H bond donor： | 0 |
| InChi： | InChI=1S// |
| InChiKey： | InChIKey=MOSFIJXAXDLOML-UHFFFAOYSA-N |
Property |
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| Comments： | APPLICATION: THE TOXIN IS RELEASED FROM B. PERTUSSIS IN AN INACTIVE FORM. WHEN THE PERTUSSIS TOXIN B OLIGOMER BINDS TO THE CELL MEMBRANE, THE S1 SUBUNIT OF ITS A PROTOMER BECOMES ACTIVATED, PERHAPS THROUGH THE ACTION OF GLUTATHIONE AND ATP. A PROTOCOL FOR ACTIVATING PERTUSSIS TOXIN IN VITRO IS GIVEN BY KASLOW, ET AL BIOCHEM/PHYSIOL ACTIONS: PERTUSSIS TOXIN CATALYZES THE ADP-RIBOSYLATION OF THE ALPHA SUBUNITS OF THE HETEROTRIMERIC GUANINE NUCLEOTIDE REGULATORY PROTEINS GI, GO, AND GT. THIS PREVENTS THE G PROTEIN HETEROTRIMERS FROM INTERACTING WITH RECEPTORS, THUS BLOCKING THEIR COUPLING AND ACTIVATION. SINCE THE GALPHA SUBUNITS REMAIN IN THEIR GDP-BOUND, INACTIVE STATE, THEY ARE UNABLE TO INACTIVATE ADENYLYL CYCLASE OR OPEN K+ CHANNELS OTHER NOTES: PERTUSSIS TOXIN-CATALYZED ADP-RIBOSYLATION OF G PROTEINS OTHER NOTES: TECHNIQUES USED IN THE IDENTIFICATION AND ANALYSIS OF FUNCTION OF PERTUSSIS TOXIN-SENSITIVE GUANINE NUCLEOTIDE BINDING PROTEINS PHYSICAL FORM: ASEPTICALLY PACKAGED SOLUTION IN 50% (V/V) GLYCEROL 50 MM TRIS, PH 7.5 10 MM GLYCINE, 0.5 M NACL RIDADR: UN 3462 6.1/PG 1 RTECS: XW5883750 STORAGE TEMPERATURE: -20 DEG C UNSPSC: 12352200 WGK: 3 |
| Information： | BIOLOGICAL SOURCE: FROM BORDETELLA PERTUSSIS |
Safety information |
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| WGK Germany： | 2 |
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