Basic Information |
|
| Product Name： | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE |
| CAS： | 30827-99-7 |
| English Synonyms： | AEBSF HYDROCHLORIDE ; PEFABLOC(R) SC ; 4-(2-AMINOETHYL)BENZENE-1-SULFONYL FLUORIDE HYDROCHLORIDE ; 4-(2-AMINOETHYL)-BENZOLSULFONYLFLUORIDE HYDROCHLORIDE ; 4-(2-AMINOETHYL)BENZENE-SULFONYL FLUORIDE ; AEBSF ; PEFABLOC(R) SC HYDROCHLORIDE ; PEFABLOC SC ; 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HCL ; AEBSF HCL ; 4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HYDROCHLORIDE ; 4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HCL ; 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE ; PEFABLOC SC PLUS ; 4-(2-AMINOETYL)-BENZENESULFONYL FLUORIDE HYDROCHLORIDE ; PEFABLOC SC HYDROCHLORIDE |
| MDL Number.： | MFCD00132962 |
| H bond acceptor： | 3 |
| H bond donor： | 1 |
| Smile： | c1cc(ccc1CCN)S(=O)(=O)F.Cl |
| InChi： | InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| InChiKey： | InChIKey=WRDABNWSWOHGMS-UHFFFAOYSA-N |
Property |
|
| Melting Point： | APPROX 183 DEG C/181-185℃ |
| Comments： | APPLICATION: RECOMMENDED CONCENTRATIONS FOR USE ARE 0.1-1 MM ASSAY METHOD: HPLC BIOCHEM/PHYSIOL ACTIONS: IRREVERSIBLE SERINE PROTEASE INHIBITOR. INHIBITION CONSTANTS ARE SIMILAR TO THOSE OF PMSF AND DFP. AEBSF HAS BEEN SHOWN TO INHIBIT TRYPSIN, CHYMOTRYPSIN, PLASMIN KALLIKREIN AND THROMBIN. AS AN ALTERNATIVE TO PMSF AND DFP, AEBSF OFFERS LOWER TOXICITY, IMPROVED SOLUBILITY IN WATER AND IMPROVED STABILITY IN AQUEOUS SOLUTIONS. AEBSF HAS BEEN USED IN CELL CULTURE IN CONCENTRATIONS OF UP TO 0.25 MM LEGAL INFORMATION: PEFABLOC IS A REGISTERED TRADEMARK OF PENTAPHARM OTHER NOTES: IN CONTRAST TO PMSF, IT IS WATER SOLUBLE AND NON-TOXIC OTHER NOTES: POTENT AND IRREVERSIBLE INHIBITOR OF SERINE PROTEASES OTHER NOTES: UNAFFECTED BY ALBUMIN RIDADR: UN 3261 8/PG 2 STORAGE TEMPERATURE: 2-8 DEG C UNSPSC: 12352200 WGK: 3 |
| Specification： | ANALYTICAL STANDARD |
Safety information |
|
| Symbol： |
GHS05
|
| Signal word： | Danger |
| Hazard statements： | H314 |
| Precautionary statements： | P280-P305 + P351 + P338-P310 |
| hazard symbol： | C |
| Risk Code： | R:34 |
| Safe Code： | S:26-36/37/39-45 |
| UN Code： | 3261 |
| WGK Germany： | 3 |
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