ASTEMIZOLE ,68844-77-9 _Chemical Cloud Database

ASTEMIZOLE

Basic Information
Product Name：	ASTEMIZOLE
CAS：	68844-77-9
English Synonyms：	1-(4-FLUOROBENZYL)-2-(1-[4-METHOXYPHENETHYL]PIPERIDIN-4-YL)AMINOBENZIMIDAZOLE ; HISMANAL ; 1-((4-FLUOROPHENYL)-METHYL)-N-(1-(2-(4-METHOXYPHENYL)ETHYL)-4-PIPERIDINYL)-1H-BENZIMIDAZOL-2-AMINE ; ASTEMIZOLE
MDL Number.：	MFCD00153919
H bond acceptor：	5
H bond donor：	1
Smile：	COc1ccc(cc1)CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(cc5)F
InChi：	InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
InChiKey：	InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N
Property
Comments：	BIOCHEM/PHYSIOL ACTIONS: NON-SEDATING ANTI-HISTAMINERGIC DRUG. SUBSTRATE FOR CYP3A. INHIBITOR OF PGP-MEDIATED DRUG EFFLUX AND PGP LABELING BY [3H]AZIDOPINE. POTENTIAL FOR COMBINATION THERAPY WITH ANTICANCER DRUGS SUCH AS DOXORUBICIN IN RESISTANT LEUKEMIA RTECS: DD8968000 UNSPSC: 12352100 WGK: 3
Safety information
Symbol：	GHS07
Signal word：	Warning
Hazard statements：	H315-H319-H335
Precautionary statements：	P261-P305 + P351 + P338
hazard symbol：	Xn
Risk Code：	R:22-36/37/38
Safe Code：	S:26-36
WGK Germany：	3

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