6-THIOGUANINE ,154-42-7 _Chemical Cloud Database

6-THIOGUANINE

Basic Information
Product Name：	6-THIOGUANINE
CAS：	154-42-7
English Synonyms：	THIOGUANINE ; 2-AMINO-1,7-DIHYDRO-6H-PURINE-6-THIONE ; 2-AMINO-3,7-DIHYDRO-6H-PURINE-6-THIONE ; 6-TG ; 2-AMINO-1,7(9)-DIHYDRO-PURINE-6-THIONE ; 6-THIOGUANINE ; 2-AMINO-6-MERCAPTOPURINE ; 2-AMINO-6-PURINETHIOL ; 6-TG/THIOGUANINE ; 6-THIOGUANINE, 98% ; TIOGUANINE ; 2-AMINO-6,7-DIHYDRO-1H-PURINE-6-THIONE ; 2-AMINO-1,7-DIHYDROPURINE-6-THIONE ; 6-MERCAPTOGUANINE
MDL Number.：	MFCD00233553
H bond acceptor：	5
H bond donor：	3
Smile：	c1[nH]c2c(=S)[nH]c(nc2n1)N
InChi：	InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChiKey：	InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N
Property
Melting Point：	=>300 DEG C(LIT)
Comments：	ASSAY METHOD: HPLC BIOCHEM/PHYSIOL ACTIONS: AS THE NUCLEOTIDE, INHIBITS A VARIETY OF CELLULAR PROCESSES INVOLVED IN NUCLEIC ACID SYNTHESIS. HAS A LONG HISTORY AS AN EFFECTIVE TREATMENT OF LEUKEMIA BIOCHEM/PHYSIOL ACTIONS: RIBOSYLATED AND PHOSPHORYLATED BY THE SAME PATHWAY AS NATURAL PURINE BASES OTHER NOTES: ANTINEOPLASTIC AGENT OTHER NOTES: SUBSTRATE FOR HGPRTASE, CONVERTED TO 6-THIO-GMP, WHICH THEN INHIBITS VITAL METABOLIC SEQUENCES IN MYELOCYTIC AND ACUTE LYMPHOCYTIC LEUKEMIA RIDADR: UN 2811 6.1/PG 3 RTECS: UP0740000 TOTAL IMPURITIES: WGK: 3
Specification：	PURUM
Concentration：	50×
Safety information
Symbol：	GHS06
Signal word：	Danger
Hazard statements：	H301
Precautionary statements：	P301 + P310
hazard symbol：	T
Risk Code：	R:25
Safe Code：	S:28-36/37/39-45
WGK Germany：	3

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