Basic Information |
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| Product Name： | GENTAMICIN SULFATE |
| CAS： | 1405-41-0 ;1403-66-3 |
| English Synonyms： | GENTAMYCINUM ; GARAMYCIN SULFATE SALT ; GENTIOMYCIN C ; GENOPTIC SULFATE ; GARAMYCIN ; GARAMYCIN SULFATE ; GENTAMYCIN SULFATE ; GM SULFATE ; O-3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-BETA-L-ARABINOPYRANOSYL-(1-6)-O-(2,6-DIAMINO-2,3,4,6-TETRADEOXY-ALPHA-D-ERYTHRO-HEXOPYRANOSYL-(1-4))-2-DEOXY-D-STREPTAMINE ; GENTACYCOL ; GENTAMICIN SULFATE ; GENTAMICIN SULFATE USP GRADE 99% ; GENTAMICIN SULFATE SALT ; GENTAMICIN C(SUB 1A) ; (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDROXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)TETRAHYDRO-2H-PYRAN-3,5-DIOL SULFATE ; GENTAMICIN ; GENTAMICIN SULFATE CELL CULTURE TESTED ; GENTAMICIN C COMPLEX SULFATE ; GENTAMICINS ; GENTAMYCIN SULPHATE ; GENTIOMYCIN C SULFATE SALT ; GENTAMICIN SULPHATE ; GENOPTIC |
| MDL Number.： | MFCD00270181 |
| H bond acceptor： | 12 |
| H bond donor： | 8 |
| Smile： | C[C@H]([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)N.C[C@H]([C@@H]1CC[C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@@H]3[C@@H]([C@H]([C@@](CO3)(C)O)NC)O)N)N)N)NC.C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CN)N)N)N)O.OS(=O)(=O)O |
| InChi： | InChI=1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1 |
| InChiKey： | InChIKey=RDEIXVOBVLKYNT-HDZPSJEVSA-N |
Property |
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| Comments： | BIOCHEM/PHYSIOL ACTIONS: MODE OF ACTION: GENTAMICIN CAUSES CODON MISREADING BY BINDING TO THE 30S RIBOSOMAL SUBUNIT, BLOCKING THE TRANSLOCATION OF PEPTIDYL-TRNA FROM THE ACCEPTOR SITE TO THE DONOR SITE. THE BACTERICIDAL EFFECT OF GENTAMICIN ON PSEUDOMONAS AERUGINOSA IS EXERTED BY THE BINDING OF GENTAMICIN TO THE OUTER MEMBRANE, WHERE IT DISPLACES NATURAL CATIONS, DESTABILIZES THE MEMBRANE, AND FORMS HOLES IN THE CELL SURFACE. ANTIMICROBIAL SPECTRUM: GRAM-NEGATIVE BACTERIA, STAPHYLOCOCCUS AUREUS AND OTHER GRAM-POSITIVE BACTERIA GENERAL DESCRIPTION: THIS PRODUCT IS PROVIDED AS DELIVERED AND SPECIFIED BY THE ISSUING PHARMACOPOEIA. ALL INFORMATION PROVIDED IN SUPPORT OF THIS PRODUCT, INCLUDING MSDS AND ANY PRODUCT INFORMATION LEAFLETS HAVE BEEN DEVELOPED AND ISSUED UNDER THE AUTHORITY OF THE ISSUING PHARMACOPOEIA. FOR FURTHER INFORMATION AND SUPPORT PLEASE GO TO THE WEBSITE OF THE ISSUING PHARMACOPOEIA OTHER NOTES: SALES RESTRICTIONS MAY APPLY |
| Concentration： | 50mg/mLgentamicin |
Safety information |
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| Symbol： |
GHS08
|
| Signal word： | Danger |
| Hazard statements： | H317-H334 |
| Precautionary statements： | P261-P280-P342 + P311 |
| hazard symbol： | Xn |
| Risk Code： | R:42/43 |
| Safe Code： | S:23-36/37-45 |
| WGK Germany： | nwg |
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