Basic Information |
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| Product Name： | N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE |
| CAS： | 132201-33-3 |
| English Synonyms： | (2R,3S)-N-BENZOYL-3-PHENYLISOSERINE ; (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONIC ACID ; SIDE CHAINS OF PACLITAXEL-4 ; (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPANOIC ACID ; METHYL(2R,3S)-3-(BENZOYLAMINO)-2-HYDROXY-3-PHENYLPROPANOALE ; N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE ; N-BENZOYL-(2R,3S)-3-AMINO-2-HYDROXY-3-PHENYL-PROPANOIC ACID ; N-BENZOYL-(2R,3S)-3-AMINO-2-HYDROXY-3-PHENYL-PROPIONIC ACID ; (2R,3S)-3-BENZAMIDO-2-HYDROXY-3-PHENYLPROPANOIC ACID |
| MDL Number.： | MFCD00274633 |
| H bond acceptor： | 5 |
| H bond donor： | 3 |
| Smile： | c1ccc(cc1)[C@@H]([C@H](C(=O)O)O)NC(=O)c2ccccc2 |
| InChi： | InChI=1S/C16H15NO4/c18-14(16(20)21)13(11-7-3-1-4-8-11)17-15(19)12-9-5-2-6-10-12/h1-10,13-14,18H,(H,17,19)(H,20,21)/t13-,14+/m0/s1 |
| InChiKey： | InChIKey=HYJVYOWKYPNSTK-UONOGXRCSA-N |
Property |
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| Melting Point： | 169-172 DEG C(LIT) |
| Comments： | APPLICATION: THE PRESENCE OF THIS CHIRAL SIDE CHAIN HAS PROVEN TO BE ESSENTIAL FOR THE BIOLOGICAL ACTIVITY OF TAXOL, ONE OF THE MOST PROMISING ANTICANCER AGENTS BEING INVESTIGATED. THE CHALLENGING SYNTHESIS OF TAXOL HAS STIMULATED INTEREST IN THE ATTACHMENT OF THE C-13 SIDE CHAIN TO NATURALLY DERIVED TAXANES LIKE BACCATIN III OPTICAL ACTIVITY: [ALPHA]20/D -40 DEG, C = 1.0 IN ETHANOL UNSPSC: 12352100 WGK: 3 |
Safety information |
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| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H315-H319-H335 |
| Precautionary statements： | P261-P305 + P351 + P338 |
| hazard symbol： | Xi |
| Risk Code： | R:36/37/38 |
| Safe Code： | S:26-36 |
| WGK Germany： | 3 |
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