Basic Information |
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| Product Name： | DOCETAXEL |
| English Synonyms： | DOCETAXEL |
| MDL Number.： | MFCD00871399 |
| H bond acceptor： | 15 |
| H bond donor： | 5 |
| Smile： | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](c5ccccc5)NC(=O)OC(C)(C)C)O)O)OC(=O)c6ccccc6)(CO4)OC(=O)C)O)C)O |
| InChi： | InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1 |
| InChiKey： | InChIKey=ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
Property |
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| Melting Point： | 186-192 DEG C (DEC) |
| Comments： | APPLICATION: DO YOU HAVE APPLICATION INFORMATION ON THIS PRODUCT THAT YOU WOULD LIKE TO SHARE APPLICATION: DOCETAXEL CAN BE USED TO STUDY ANTIBIOTICS, CELL BIOLOGY, CELL SIGNALING, NEUROSCIENCE AND APOPTOSIS AND THE CELL CYCLE. DOCETAXEL HAS BEEN USED TO STUDY THE PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA, AS WELL AS THE TREATMENT OF NON-SMALL-CELL LUNG CANCER IN PATIENTS CONTRAINDICATED FOR STANDARD CHEMOTHERAPY. DOCETAXEL HAS ALSO BEEN USED TO STUDY THE ROLE OF HYPOXIA-INDUCIBLE FACTOR-1ALPHA AND -2ALPHA IN ANDROGEN INSENSITIVE PROSTATE CANCER CELLS ASSAY METHOD: HPLC BIOCHEM/PHYSIOL ACTIONS: DOCETAXEL IS A TAXANE ANTI-CANCER AGENT RELATED TO PACLITAXEL. IT BINDS TO AND STABILIZES THE BETA-TUBULIN SUBUNIT OF MICROTUBULES, PREVENTING DEPOLYMERIZATION OF THE MITOTIC SPINDLE THUS LEADING TO CELL CYCLE ARREST AND APOPTOSIS FREQUENTLY ASKED QUESTIONS: LIVE CHAT AND FREQUENTLY ASKED QUESTIONS ARE AVAILABLE FOR THIS PRODUCT RTECS: DA4172750 SOLUBILITY: DO YOU HAVE SOLUBILITY INFORMATION ON THIS PRODUCT THAT YOU WOULD LIKE TO SHARE TOTAL IMPURITIES: APPROX 6% WATER UNSPSC: 12352200 WGK: 3 |
| Specification： | PURUM |
Safety information |
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