Basic Information |
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| Product Name： | AMLODIPINE BESYLATE |
| CAS： | 111470-99-6 ;88150-42-9 |
| English Synonyms： | NORVASC BESYLATE ; AMLODIPINE BENZENESULFONATE SALT ; 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE ; AMLODIPINE BESILATE ; AMLODIPINE ; AMLODIPINE BENZENESULPHONATE ; AMLODIPINE BENZENESULFONATE ; ISTIN ; NORVASC ; 2-(2-AMINO-ETHOXYMETHYL)-4-(2-CHLORO-PHENYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER COMPOUND WITH BENZENESULFONIC ACID ; 3-ETHYL-5-METHYL 2-(AMINOETHOXYMETHYL)-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYLPYRIDINE-3,5-DICARBOXYLATE BENZENESULFONATE SALT ; AMLODIPINE BESYLATE ; 3-ETHYL 5-METHYL 2-(2-AMINOETHOXY)METHYL-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE BENZENESULFONATE |
| MDL Number.： | MFCD00887594 |
| H bond acceptor： | 7 |
| H bond donor： | 2 |
| Smile： | CCOC(=O)C1=C(NC(=C(C1c2ccccc2Cl)C(=O)OC)C)COCCN.c1ccc(cc1)S(=O)(=O)O |
| InChi： | InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9) |
| InChiKey： | InChIKey=ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
Property |
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| Melting Point： | 195-204℃ |
| Boiling Point： | MP: 198-200 DEG |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: AMLODIPINE IS AN L-TYPE CALCIUM CHANNEL BLOCKER. AMLODIPINE BELONGS TO A CLASS OF CARDIOVASCULAR DRUGS, WHICH ACT AT THE VOLTAGE GATED CALCIUM CHANNEL OF THE CAV1, OR L-TYPE, CLASS. AMLODIPINE ALSO HAS ANTIHYPERTENSIVE AND ANTIANGINAL EFFECTS. ITS ACTIVITY RESIDES MAINLY IN THE (-)-ISOMER. AMLODIPINE INHIBITS GROWTH OF HUMAN EPIDERMOID CARCINOMA A431 CELLS AND HAS ANTIREPRODUCTIVE EFFECTS IN MALE RATS GENERAL DESCRIPTION: THIS PRODUCT IS PROVIDED AS DELIVERED AND SPECIFIED BY THE ISSUING PHARMACOPOEIA. ALL INFORMATION PROVIDED IN SUPPORT OF THIS PRODUCT, INCLUDING MSDS AND ANY PRODUCT INFORMATION LEAFLETS HAVE BEEN DEVELOPED AND ISSUED UNDER THE AUTHORITY OF THE ISSUING PHARMACOPOEIA. FOR FURTHER INFORMATION AND SUPPORT PLEASE GO TO THE WEBSITE OF THE ISSUING PHARMACOPOEIA OTHER NOTES: SALES RESTRICTIONS MAY APPLY |
Safety information |
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| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H302,H315,H319,H335 |
| Precautionary statements： | P261,P305+P351+P338 |
| hazard symbol： | Xn |
| Risk Code： | R:R22;R36/37/38 |
| Safe Code： | S:S26;S36 |
| WGK Germany： | 3 |
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