GSK2801_Chemical Cloud Database

GSK2801

Basic Information
Product Name：	GSK2801
English Synonyms：	GSK 280 ; GSK-2801 ; 1-(7-(2-METHYLSULFONYL-PHENYL)-4-PROPOXY-1-AZA-BICYCLO[4.3.0]NONA-2,4,6,8-TETRAEN-9-YL)-ETHANONE ; GSK2801
H bond acceptor：	0
H bond donor：	0
Smile：	CS(=O)(=O)C1=C(C=CC=C1)C1=C2C=C(C=CN2C(=C1)C(C)=O)OCCC
InChi：	InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
InChiKey：	InChIKey=KHWCPNJRJCNVRI-UHFFFAOYSA-N
Property
Comments：	GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins. BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifying enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. For the detailed information of GSK2801, the solubility of GSK2801 in water, the solubility of GSK2801 in DMSO, the solubility of GSK2801 in PBS buffer, the animal experiment (test) of GSK2801, the cell expriment (test) of GSK2801, the in vivo, in vitro and clinical trial test of GSK2801, the EC50, IC50,and affinity,of GSK2801
Safety information

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