NS6180 ,353262-04-1 _Chemical Cloud Database

NS6180

Basic Information
Product Name：	NS6180
CAS：	353262-04-1
English Synonyms：	NS6180 ; NS-6180 ; 4-[[3-(TRIFLUOROMETHYL)PHENYL]METHYL]-2H-1,4-BENZOTHIAZIN-3(4H)-ONE
H bond acceptor：	0
H bond donor：	0
Smile：	FC(C=1C=C(C=CC1)CN1C(CSC2=C1C=CC=C2)=O)(F)F
InChi：	InChI=1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
InChiKey：	InChIKey=ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Property
Comments：	NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1) The IC50 of NS6180 against cloned human KCa3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.
Specification：	NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1)
Safety information

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