BG-45 ,926259-99-6 _Chemical Cloud Database

BG-45

Basic Information
Product Name：	BG-45
CAS：	926259-99-6
English Synonyms：	BG45 ; BG-45 ; N-(2-AMINOPHENYL)-2-PYRAZINECARBOXAMIDE
H bond acceptor：	0
H bond donor：	0
Smile：	NC1=C(C=CC=C1)NC(=O)C1=NC=CN=C1
InChi：	InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
InChiKey：	InChIKey=LMWPVSNHKACEKW-UHFFFAOYSA-N
Property
Comments：	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50?= 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma
Specification：	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50= 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).
Safety information

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