KN92 phosphate

CAS No.
1135280-28-2
CCD No.
CCD08293438
Formula
C24H25ClN2O3S.H3PO4
MolWeight
554.98

Basic Information

Product Name: KN92 phosphate
CAS: 1135280-28-2
English Synonyms: KN 92 ; N-[2-({[(2E)-3-(4-CHLOROPHENYL)PROP-2-EN-1-YL](METHYL)AMINO}METHYL)PHENYL]-4-METHOXYBENZENESULFONAMIDE; PHOSPHORIC ACID ; KN92 PHOSPHATE ; KN92 ; 2-[N-(4'-METHOXYBENZENESULFONYL)]AMINO-N-(4'-CHLOROPHENYL)-2-PROPENYL-N-METHYLBENZYLAMINEPHOSPHATE
H bond acceptor: 0
H bond donor: 0
Smile: P(O)(O)(O)=O.ClC1=CC=C(C=C1)/C=C/CN(C)CC1=C(C=CC=C1)NS(=O)(=O)C1=CC=C(C=C1)OC
InChi: InChI=1S/C24H25ClN2O3S.H3O4P/c1-27(17-5-6-19-9-11-21(25)12-10-19)18-20-7-3-4-8-24(20)26-31(28,29)23-15-13-22(30-2)14-16-23;1-5(2,3)4/h3-16,26H,17-18H2,1-2H3;(H3,1,2,3,4)/b6-5+;
InChiKey: InChIKey=XRQHWVVDNMJDEQ-IPZCTEOASA-N

Property

Information: KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

Safety information

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